Phenolic constituents from twigs of Aleurites fordii and their biological activities

• Kyoung Jin Park,
• Won Se Suh,
• Da Hye Yoon,
• Chung Sub Kim,
• Sun Yeou Kim and
• Kang Ro Lee

Beilstein J. Org. Chem. 2021, 17, 2329–2339, doi:10.3762/bjoc.17.151

• fordii; antineuroinflammation; Euphorbiaceae; neolignan glycoside; neuroprotective activity; phenolic compound; Introduction Aleurites fordii Hemsl. (= Vernicia fordii Hemsl., Euphorbiaceae), known as tung oil tree, is widely distributed throughout Northeast Asia [1]. The fruits, leaves, and roots of

[2 + 1] Cycloaddition reactions of fullerene C₆₀ based on diazo compounds

• Yuliya N. Biglova

Beilstein J. Org. Chem. 2021, 17, 630–670, doi:10.3762/bjoc.17.55

• fundamentally new architecture appears [38]. The neuroprotective activity of fullerene derivatives may not be ignored either. Encouraging results of their use for the treatment of neurodegenerative pathologies (Alzheimer's and Parkinson's diseases and other diseases accompanied by cognitive impairment) leading

Current understanding and biotechnological application of the bacterial diterpene synthase CotB2

• Ronja Driller,
• Daniel Garbe,
• Norbert Mehlmer,
• Monika Fuchs,
• Keren Raz,
• Dan Thomas Major,
• Thomas Brück and
• Bernhard Loll

Beilstein J. Org. Chem. 2019, 15, 2355–2368, doi:10.3762/bjoc.15.228

• substances, in addition to being key flavor ingredients [78], play a major role in the defence against insects, pathogenic microbes and herbivores [79]. Furthermore, β-CBT 17 showed additional antibiotic activity against multidrug resistant S. aureus strains, [80], as well as neuroprotective activity [81

Biomimetic synthesis and HPLC–ECD analysis of the isomers of dracocephins A and B

• Viktor Ilkei,
• András Spaits,
• Anita Prechl,
• Áron Szigetvári,
• Zoltán Béni,
• Miklós Dékány,
• Csaba Szántay Jr,
• Judit Müller,
• Árpád Könczöl,
• Ádám Szappanos,
• Attila Mándi,
• Sándor Antus,
• Ana Martins,
• Attila Hunyadi,
• György Tibor Balogh,
• György Kalaus (†),
• Hedvig Bölcskei,
• László Hazai and
• Tibor Kurtán

Beilstein J. Org. Chem. 2016, 12, 2523–2534, doi:10.3762/bjoc.12.247

• the other hand, the possibility for neuroprotective activity could not be tested with the applied experimental setup. As an additional bioassay on compounds 2a–d and 3a–d, their potential to interfere with the function of P-glycoprotein (P-gp) was tested. By transporting a wide variety of compounds

Preparation of neuroprotective condensed 1,4-benzoxazepines by regio- and diastereoselective domino Knoevenagel–[1,5]-hydride shift cyclization reaction

• László Tóth,
• Yan Fu,
• Hai Yan Zhang,
• Attila Mándi,
• Katalin E. Kövér,
• Tünde-Zita Illyés,
• Attila Kiss-Szikszai,
• Balázs Balogh,
• Tibor Kurtán,
• Sándor Antus and
• Péter Mátyus

Beilstein J. Org. Chem. 2014, 10, 2594–2602, doi:10.3762/bjoc.10.272

• rac-5 were tested against hydrogen peroxide (H2O2), β-amyloid-25-35 (Aβ25–35) and oxygen–glucose deprivation (OGD)-induced neurotoxicity in human neuroblastoma SH-SY5Y cells [22]. The preliminary screenings showed that rac-7a at 10 µM concentration displayed neuroprotective activity against H2O2

• configurations of 7a,b were assigned to the separated enantiomers showing positive CE for the lowest-energy ECD transition by the comparison of the experimental HPLC-ECD spectra with those obtained by the TDDFT-ECD calculations of the solution conformers. Compound 7a showed neuroprotective activity against

• strengths. Boltzmann distributions were estimated from the ZPVE-corrected B3LYP/6-31G(d) energies in the gas-phase calculations and from the B3LYP/TZVP energies in the PCM ones. The MOLEKEL [28] software package was used for visualization of the results. Bioassay on neuroprotective activity: SH-SY5Y cells